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Honey for Cold Sores: What a Comparison With Acyclovir Showed

Honey for cold sores is a home remedy with a small but interesting study behind it. In 2004, researchers compared honey with acyclovir cream, a common antiviral treatment, in people with recurring cold sores and genital herpes. Honey shortened healing time in that small group. It is a single small study, so it is not proof, but it explains why people try honey on cold sores. This article covers what cold sores are, the research on honey for cold sores, safe use and when antiviral medicine is the better choice. For mouth sores inside the mouth, see honey for mouth ulcers.

For general education only, not medical advice. Our honey is a food and is not intended to diagnose, treat, cure or prevent any disease.

What cold sores are

Cold sores are small, painful blisters, usually on or around the lips, caused by the herpes simplex virus, most often type 1. After the first infection, the virus stays dormant in nerves and can reactivate, triggered by stress, illness, sun, fever or hormonal changes.

Outbreaks typically start with tingling or burning, followed by blisters that break, crust and heal over about one to two weeks.

The 2004 honey for cold sores study

Researcher Noori Al-Waili published Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions in Medical Science Monitor in 2004. Sixteen adults with recurring cold sores or genital herpes used honey for one outbreak and acyclovir cream for another.

For cold sores, honey was linked with shorter healing time and less pain compared with acyclovir. The study was small, not blinded, and has not been confirmed by larger trials.

  • 16 adults.
  • Each person tried honey and acyclovir on different outbreaks.
  • Honey applied four times a day.
  • Not blinded and not repeated in large trials.

Why honey for cold sores might help

Lab studies show honey has some activity against herpes simplex virus, as our article on honey antiviral research explains. Honey also keeps sores moist and covered, which may reduce cracking and discomfort.

These are plausible reasons, but more research is needed.

How people use honey for cold sores

In the study, honey was applied on gauze four times a day. At home, people dab a small amount on the sore with a clean cotton swab, using a fresh swab each time to avoid contaminating the jar.

Wash hands before and after touching a cold sore. Do not double-dip into a shared honey jar.

Antiviral treatments

Prescription antiviral pills like valacyclovir, acyclovir and famciclovir can shorten outbreaks, especially when started at the first tingle. Over-the-counter docosanol cream may also help a little. People with frequent outbreaks may take daily antivirals to prevent them.

OptionEvidence
Oral antivirals (prescription)Strong; best when started early
Docosanol cream (OTC)Modest
Acyclovir creamModest
HoneyOne small study
Sun protection for lipsHelps prevent sun-triggered outbreaks

Preventing spread

Cold sores are contagious, especially when blisters are open. Avoid kissing, sharing utensils, cups, lip balm or towels during an outbreak. Be especially careful around babies, people with eczema and anyone with a weakened immune system.

Babies and cold sores

Herpes simplex can be very dangerous for newborns. Anyone with a cold sore should avoid kissing babies. Never use honey on or near a baby's mouth, since babies under 12 months must not swallow honey.

When to see a doctor

See a doctor if cold sores are frequent, severe, spread to the eyes, do not heal within two weeks, or if you have a weakened immune system. Eye involvement needs urgent care because it can damage vision.

Honey for cold sores and lip care

Between outbreaks, keeping lips moisturized and protected from sun helps. Lip balms with SPF can reduce sun-triggered outbreaks. Our article on honey for lips covers honey in lip care.

Patch test and allergies

People with pollen or bee product allergies can react to honey on the skin. Try a tiny amount on the inner arm first. Stop if it stings or reddens.

What to take away

Honey for cold sores is a gentle option with a little research support. If you have frequent or painful outbreaks, ask your doctor about antivirals, which have much stronger evidence.

Honey for cold sores at the first tingle

Most cold sore treatments work best when started early, at the tingling stage before blisters appear. If you want to try honey for cold sores, starting at the first sign may make sense. If you have antiviral medicine prescribed, take it as soon as symptoms begin.

Some people keep a small pot of honey and a supply of cotton swabs set aside specifically for this purpose, separate from their kitchen jar.

Common triggers

Knowing your triggers can reduce outbreaks. Common ones include strong sun, colds and fevers, stress, lack of sleep, hormonal changes and lip injury. Using lip balm with SPF and managing stress are simple preventive habits.

Honey for eating

Al Safa honey is raw food honey, never heated above hive temperature. If you use honey on skin, keep a separate small amount for that purpose rather than dipping into the family jar.

Browse our honeys in the shop.

Sources

Outside health sources we used for this article. They open in a new tab.

  1. Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions (2004) · Medical Science Monitor
  2. Honey in dermatology and skin care: a review (Journal of Cosmetic Dermatology, 2013) · PubMed
  3. Honey (drugs and supplements) · Mayo Clinic

Frequently asked questions

Does honey help cold sores?
A small 2004 study found honey shortened healing compared with acyclovir cream, but evidence is limited.
How often should I apply honey to a cold sore?
The study used four times a day. Use a clean swab each time.
Is honey better than antiviral medicine?
Oral antivirals have stronger evidence, especially when started early.
Can I share a honey jar if I have a cold sore?
Avoid double-dipping. Use a separate small portion for the sore.
Is manuka honey better for cold sores?
There is no strong evidence comparing honey types for cold sores.
When is a cold sore serious?
If it spreads to the eyes, is very frequent or severe, or you have a weakened immune system.

Al Safa Honey is a food producer, not a medical provider. Nothing here is medical advice, and these statements have not been evaluated by the Food and Drug Administration. Talk to your doctor about any health concern. Never give honey of any kind to a baby under 12 months old.